Travel from airport to hotel. Taxis are readily available. The cost of a taxi from LaGuardia to mid-town, the location of the Sheraton, is about $50. If there are several persons, additional charges apply. Be prepared to pay abridge toll as well, and perhaps even additional for extra luggage.
An alternative to a taxi can be less expensive. A shuttle (really a large 45-passenger bus!) runs from the airport to Grand Central Station for about $12. Once at Grand Central Station, a taxi to the hotel is less than $10. This web site will give you an idea: http://www.nycairporter.com/